RBC FluoGene D® weak/variant
Inno-train
Weak D blood types have varying point mutations reducing Rh/D antigen, impacting agglutination. RBC FluoGene D detects most common weak D alleles and DEL alleles.
The molecular characteristics of the weak D types are different point mutations, each causing an amino acid exchange in the intracellular or transmembrane region of the affected antigen. The resulting lower concentration of Rh/D epitopes on the erythrocyte membrane depends on the weak D type presence and can lead to a strong attenuation of agglutination in the classical hemagglutination test. The RBC FluoGene D weak/variant detects the most common weak D alleles (type 1, 1.1, 2, 3, 4, 4.0, 4.1, 4.2, 4.3, 5, 15 and 17), as well as the DEL alleles RHD*01EL.01, and RHD*01EL.08.
Features
- Low DNA consumption, e.g. 150 ng per typing with RBC-FluoGeneNX ABO plus.
- Same method like with HLA- and RBC-FluoGene® via fluorescence detection.
- Hands-on time: less than 5 minutes.
- Assay duration: more than 1 hour.
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